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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Progression 0% Improvement Relative Risk Progression (b) 34% Time to progression 13% c19fluvoxamine.com Seo et al. Fluvoxamine for COVID-19 RCT EARLY TREATMENT Favors fluvoxamine Favors control
Fluvoxamine Treatment of Patients with Symptomatic COVID-19 in a Community Treatment Center: A Preliminary Result of Randomized Controlled Trial
Seo et al., Infection & Chemotherapy, doi:10.3947/ic.2021.0142
3 Mar 2022    Source   PDF   Share   Tweet
Early terminated RCT with 52 COVID+ patients in South Korea, showing no significant difference in progression with fluvoxamine treatment. There were only 2 events in each arm, and only one event for fluvoxamine in PP analysis. The trial was terminated early because the treatment center closed. 100mg fluvoxamine bid for 10 days.
risk of progression, no change, RR 1.00, p = 1.00, treatment 2 of 26 (7.7%), control 2 of 26 (7.7%).
risk of progression, 34.2% lower, RR 0.66, p = 1.00, treatment 1 of 19 (5.3%), control 2 of 25 (8.0%), NNT 37, PP.
time to progression, 13.3% lower, relative time 0.87, p = 0.16, treatment mean 6.5 (±0.7) n=26, control mean 7.5 (±3.5) n=26.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Seo et al., 3/3/2022, Single Blind Randomized Controlled Trial, placebo-controlled, South Korea, Asia, peer-reviewed, median age 53.5, 14 authors, study period 15 January, 2021 - 19 February, 2021.
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