COVID-19 studies:  C19 studies: C19:  IvermectinIVM Vitamin DV.D PXPX FLVFLV PVP-IPI BUBU BHBH BLBL CICI HC QHC Q NZNZ COCO More..
 
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00.250.50.7511.251.51.752+Lenze (DB RCT)0.07[0.00-1.28]progression0/806/72RRCITreatmentControlSeftel (QR)0.16[0.01-3.29]death/ICU0/772/48Tau​2 = 0.00; I​2 = 0.0%Early treatment0.11[0.01-0.85]0/1578/12089% improvementAll studies0.11[0.01-0.85]0/1578/12089% improvement2 fluvoxamine COVID-19 studiesc19fluvoxamine.com 5/12/21Tau​2 = 0.00; I​2 = 0.0%; Z = 2.12 (p = 0.017)Lower RiskIncreased Risk
To join a fluvoxamine trial in the US see https://stopcovidtrial.wustl.edu/, and in Canada see https://stopcovid2.idtrials.com/.
4/20
Review Sukhatme et al., Front. Pharmacol., doi:10.3389/fphar.2021.652688 (Review) (Peer Reviewed) review Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19
Review of mechanisms of action of fluvoxamine and other SSRIs that could be beneficial for COVID-19 treatment, including lower platelet aggregation, decreased mast cell degranulation, interference with endolysosomal viral trafficking, reg..
3/6
Review Kirsch, S. (Review) (Preprint) review COVID FAQ
COVID FAQ from the founder of the COVID-19 Early Treatment Fund [1], including an extensive analysis of the fluvoxamine trials and other supporting evidence.
2/1
Early Seftel et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab050 (Peer Reviewed) death/ICU, ↓83.9%, p=0.15 Prospective cohort of fluvoxamine for early treatment of COVID-19
Prospective quasi-randomized (patient choice) study with 125 outpatients, 77 treated with fluvoxamine, showing lower death/ICU admission (0 of 77 vs. 2 of 48), lower hospitalization (0 of 77 vs. 6 of 48), and faster recovery with treatmen..
11/12
Early Lenze et al., JAMA, doi:10.1001/jama.2020.22760 (Peer Reviewed) progression, ↓92.7%, p=0.009 Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial
RCT 152 outpatients, 80 treated with fluvoxamine showing lower progression with treatment (0 of 80 versus 6 of 72 control).
8/17
Late Hoertel et al., Molecular Psychiatry, doi:10.1038/s41380-021-01021-4 (Peer Reviewed) Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study
Retrospective 7,230 hospitalized COVID-19 patients in France, 345 receiving an antidepressant medication within 48 hours of admission. There was a significant association between antidepressant use and reduced risk of intubation or death ..
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