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0 0.5 1 1.5 2+ Progression 93% Improvement Relative Risk Hospitalization 82% c19fluvoxamine.com Lenze et al. NCT04342663 Fluvoxamine RCT EARLY TREATMENT Favors fluvoxamine Favors control
Lenze, 152 patient fluvoxamine early treatment RCT: 93% lower progression [p=0.009] and 82% lower hospitalization [p=0.009] https://c19p.org/lenze
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Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial
12 Nov 2020    Source   PDF   Share   Tweet
RCT 152 outpatients, 80 treated with fluvoxamine showing lower progression with treatment (0 of 80 versus 6 of 72 control). STOP COVID trial. NCT04342663 (history).
risk of progression, 92.7% lower, RR 0.07, p = 0.009, treatment 0 of 80 (0.0%), control 6 of 72 (8.3%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), clinical deterioration over 15 days.
risk of hospitalization, 82.0% lower, RR 0.18, p = 0.009, treatment 1 of 80 (1.2%), control 5 of 72 (6.9%), NNT 18, COVID-19 hospitalization within 15 days, see supplemental appendix for details.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lenze et al., 12 Nov 2020, Double Blind Randomized Controlled Trial, USA, peer-reviewed, 11 authors, average treatment delay 4.0 days, trial NCT04342663 (history).
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