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Fluvoxamine study #3   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Death/ICU 84% Imp. Relative Risk, 95% CI Hospitalization 94% Recovery 99% Seftel: Prospective cohort of fluvoxamine for early treatment of.. c19fluvoxamine.com/seftel.html Favors fluvoxamine Favors control
2/1 Early treatment study
Seftel et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab050 (Peer Reviewed)
Prospective cohort of fluvoxamine for early treatment of COVID-19
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Prospective quasi-randomized (patient choice) study with 125 outpatients, 77 treated with fluvoxamine, showing lower death/ICU admission (0 of 77 vs. 2 of 48), lower hospitalization (0 of 77 vs. 6 of 48), and faster recovery with treatment. Note that 12 treatment patients were added but are not reflected in the table in the paper (because the numbers had been previously published and the IRB did not allow updating the table).
risk of death/ICU, 83.9% lower, RR 0.16, p = 0.15, treatment 0 of 77 (0.0%), control 2 of 48 (4.2%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 94.0% lower, RR 0.06, p = 0.003, treatment 0 of 77 (0.0%), control 6 of 48 (12.5%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no recovery, 98.7% lower, RR 0.01, p < 0.001, treatment 0 of 77 (0.0%), control 29 of 48 (60.4%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Seftel et al., 2/1/2021, prospective quasi-randomized (patient choice), USA, North America, peer-reviewed, 2 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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