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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Death/ICU 84% Improvement Relative Risk Hospitalization 94% Recovery 99% c19fluvoxamine.com Seftel et al. Fluvoxamine for COVID-19 EARLY TREATMENT Favors fluvoxamine Favors control
Seftel, 125 patient fluvoxamine early treatment study: 84% lower combined mortality/ICU admission [p=0.15], 94% lower hospitalization [p=0.003], and 99% improved recovery [p<0.0001] https://c19p.org/seftel
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Prospective cohort of fluvoxamine for early treatment of COVID-19
Seftel et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab050
1 Feb 2021    Source   PDF   Share   Tweet
Prospective quasi-randomized (patient choice) study with 125 outpatients, 77 treated with fluvoxamine, showing lower death/ICU admission (0 of 77 vs. 2 of 48), lower hospitalization (0 of 77 vs. 6 of 48), and faster recovery with treatment. Note that 12 treatment patients were added but are not reflected in the table in the paper (because the numbers had been previously published and the IRB did not allow updating the table).
risk of death/ICU, 83.9% lower, RR 0.16, p = 0.15, treatment 0 of 77 (0.0%), control 2 of 48 (4.2%), NNT 24, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 94.0% lower, RR 0.06, p = 0.003, treatment 0 of 77 (0.0%), control 6 of 48 (12.5%), NNT 8.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no recovery, 98.7% lower, RR 0.01, p < 0.001, treatment 0 of 77 (0.0%), control 29 of 48 (60.4%), NNT 1.7, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Seftel et al., 2/1/2021, prospective quasi-randomized (patient choice), USA, North America, peer-reviewed, 2 authors.
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