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0 0.5 1 1.5 2+ Mortality 2% Improvement Relative Risk c19fluvoxamine.com Rauchman et al. Fluvoxamine for COVID-19 Prophylaxis Favors fluvoxamine Favors control
Rauchman, fluvoxamine prophylaxis study: 2% lower mortality [p=0.83] https://c19p.org/rauchman
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Ongoing use of SSRIs and the hospital course of COVID-19 patients: a retrospective outcome analysis
Rauchman et al., medRxiv, doi:10.1101/2021.10.25.21265218 (Preprint)
26 Oct 2021    Source   PDF   Share   Tweet
Retrospective 9,043 COVID-19+ patients in the USA, 832 with existing SSRI use, showing no significant difference in mortality. None of the patients were on fluvoxamine. Authors note that specific SSRIs such as fluvoxamine may be effective, and that fluvoxamine is a sigma-1 receptor (S1R) agonist and has the strongest binding affinity to S1R of all SSRIs.
risk of death, 2.0% lower, OR 0.98, p = 0.83, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rauchman et al., 26 Oct 2021, retrospective, USA, preprint, 6 authors.
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