Rauchman: Ongoing use of SSRIs and the hospital course of COVID-19 patients: a retrospective outcome analysis

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Fluvoxamine study #8 Meta Analysis

10/26 Prophylaxis study

Rauchman et al., medRxiv, doi:10.1101/2021.10.25.21265218 (Preprint)
Ongoing use of SSRIs and the hospital course of COVID-19 patients: a retrospective outcome analysis

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Retrospective 9,043 COVID-19+ patients in the USA, 832 with existing SSRI use, showing no significant difference in mortality. None of the patients were on fluvoxamine. Authors note that specific SSRIs such as fluvoxamine may be effective, and that fluvoxamine is a sigma-1 receptor (S1R) agonist and has the strongest binding affinity to S1R of all SSRIs.

risk of death, 2.0% lower, RR 0.98, p = 0.83, RR approximated with OR.

Rauchman et al., 10/26/2021, retrospective, USA, North America, preprint, 6 authors.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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