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0 0.5 1 1.5 2+ Mortality -58% Improvement Relative Risk Mortality (b) 26% c19fluvoxamine.com Oskotsky et al. Fluvoxamine for COVID-19 Prophylaxis Favors fluvoxamine Favors control
Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants
Oskotsky et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.33090
15 Nov 2021    Source   PDF   Share   Tweet
Retrospective database analysis of 83,584 patients in the USA, showing lower mortality with existing fluoxetine use in PSM analysis. There were 11 fluvoxamine patients, showing non-statistically significant higher mortality.
risk of death, 57.9% higher, RR 1.58, p = 0.62, treatment 2 of 11 (18.2%), control 19 of 165 (11.5%), fluvoxamine.
risk of death, 26.0% lower, RR 0.74, p = 0.04, treatment 48 of 481 (10.0%), control 956 of 7,215 (13.3%), NNT 31, fluoxetine.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Oskotsky et al., 15 Nov 2021, retrospective, propensity score matching, USA, peer-reviewed, 8 authors.
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