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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Death/intubation 42% Improvement Relative Risk c19fluvoxamine.com/hoertel3.html Favors fluvoxamine Favors control
29 May 2021 - Prophylaxis study
Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study
Hoertel et al., Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.2317 (Peer Reviewed)
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Retrospective 2,846 severe COVID-19 patients in France, 277 taking a FIASMA medication, showing lower risk of intubation of death with FIASMA use.
risk of death/intubation, 42.0% lower, RR 0.58, p < 0.001, treatment 104 of 277 (37.5%), control 1,064 of 2,569 (41.4%), NNT 26, adjusted per study, IPW multivariable Cox regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Hoertel et al., 5/29/2021, retrospective, France, Europe, peer-reviewed, 78 authors.
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