Fritz: Association between antidepressant use and ED or hospital visits in outpatients with SARS-CoV-2

Association between antidepressant use and ED or hospital visits in outpatients with SARS-CoV-2

Fritz et al., Translational Psychiatry, doi:10.1038/s41398-022-02109-3

22 Aug 2022 Source PDF Share Tweet

Retrospective 25,034 COVID+ outpatients showing significantly lower ER/hospitalization with antidepressants and FIASMA antidepressants, and a dose-dependent response.

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risk of hospitalization/ER, 19.4% lower, RR 0.81, p = 0.69, treatment 4 of 17 (23.5%), control 1,896 of 20,457 (9.3%), adjusted per study, odds ratio converted to relative risk, fluvoxamine, multivariable.

risk of hospitalization/ER, 11.9% lower, RR 0.88, p = 0.03, treatment 707 of 3,414 (20.7%), control 1,896 of 20,457 (9.3%), adjusted per study, odds ratio converted to relative risk, FIASMA, multivariable.

risk of hospitalization/ER, 11.9% lower, RR 0.88, p = 0.04, treatment 559 of 2,744 (20.4%), control 1,896 of 20,457 (9.3%), adjusted per study, odds ratio converted to relative risk, SSRI, multivariable.

risk of hospitalization/ER, 10.1% lower, RR 0.90, p = 0.04, treatment 971 of 4,577 (21.2%), control 1,896 of 20,457 (9.3%), adjusted per study, odds ratio converted to relative risk, all antidepressants, multivariable.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Fritz et al., 22 Aug 2022, retrospective, USA, peer-reviewed, 5 authors, study period 1 March, 2020 - 16 May, 2021.

Contact: bafritz@wustl.edu.

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