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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 41% Improvement Relative Risk c19fluvoxamine.com/darquennes.html Favors fluvoxamine Favors control
7 March 2021 - Prophylaxis study
Association between Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) and Reduced Risk of Death in COVID-19 Patients: A Retrospective Cohort Study
Darquennes et al., Pharmaceuticals, doi:10.3390/ph14030226 (Peer Reviewed)
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Retrospective 350 COVID-19 hospitalized patients in Belgium, showing lower mortality with existing long-term FIASMA treatment, not quite reaching statistical significance for all FIASMA medications, but reaching statistical significance for amlodipine.
risk of death, 41.3% lower, RR 0.59, p = 0.06, treatment 93, control 257, odds ratio converted to relative risk, multivariable logistic regression, control prevalance approximated with overall prevalence.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Darquennes et al., 3/7/2021, retrospective, Belgium, Europe, peer-reviewed, 4 authors.
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