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Fluvoxamine study #9   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 42% Imp. Relative Risk, 95% CI Calusic: Safety and efficacy of fluvoxamine in COVID-19 ICU patie.. c19fluvoxamine.com/calusic.html Favors fluvoxamine Favors control
11/1 Late treatment study
Calusic et al., British Journal of Clinical Pharmacology, doi:10.1111/bcp.15126 (Peer Reviewed)
Safety and efficacy of fluvoxamine in COVID-19 ICU patients: an open label, prospective cohort trial with matched controls
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Prospective PSM study of 51 COVID-19 ICU patients in Croatia and 51 matched controls, showing significantly lower mortality with treatment.
risk of death, 42.0% lower, RR 0.58, p = 0.03, treatment 30 of 51 (58.8%), control 39 of 51 (76.5%), adjusted per study, propensity score matching.
Calusic et al., 11/1/2021, prospective, propensity score matching, Croatia, Europe, peer-reviewed, 7 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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