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0 0.5 1 1.5 2+ Death/intubation 44% Improvement Relative Risk c19fluvoxamine.com Hoertel et al. Fluvoxamine for COVID-19 LATE Favors fluvoxamine Favors control
Hoertel, 7,230 patient fluvoxamine late treatment study: 44% lower combined mortality/intubation [p<0.0001] https://c19p.org/hoertel
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Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study
Hoertel et al., Molecular Psychiatry, doi:10.1038/s41380-021-01021-4
17 Aug 2020    Source   PDF   Share   Tweet
Retrospective 7,230 hospitalized COVID-19 patients in France, 345 receiving an antidepressant medication within 48 hours of admission. There was a significant association between antidepressant use and reduced risk of intubation or death. There was only one patient for fluvoxamine.
risk of death/intubation, 44.0% lower, RR 0.56, p < 0.001, treatment 84 of 345 (24.3%), control 1,188 of 6,885 (17.3%), adjusted per study, IPW multivariable Cox regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hoertel et al., 17 Aug 2020, retrospective, France, peer-reviewed, 17 authors.
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