Pineda: Impact of Fluvoxamine on outpatient treatment of COVID-19 in Honduras

Pineda, 657 patient fluvoxamine early treatment study: 96% lower mortality [p=0.005], 77% lower need for oxygen therapy [p=0.0004], and 54% lower hospitalization [p=0.04] https://c19p.org/pineda

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Impact of Fluvoxamine on outpatient treatment of COVID-19 in Honduras

Pineda et al., medRxiv, doi:10.1101/2022.09.27.22280428 (Preprint)

4 Oct 2022 Source PDF Share Tweet

Prospective study of 657 COVID+ outpatients in Honduras, 594 accepting fluvoxamine treatment, showing significantly lower mortality and hospitalization with treatment.

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risk of death, 95.6% lower, RR 0.04, p = 0.005, treatment 1 of 594 (0.2%), control 4 of 63 (6.3%), NNT 16, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, multivariable.

risk of oxygen therapy, 76.8% lower, RR 0.23, p < 0.001, treatment 21 of 594 (3.5%), control 12 of 63 (19.0%), NNT 6.4, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, multivariable.

risk of hospitalization, 53.7% lower, RR 0.46, p = 0.04, treatment 30 of 594 (5.1%), control 10 of 63 (15.9%), NNT 9.2, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, multivariable.

hospitalization time, 35.5% higher, relative time 1.36, p = 0.33, treatment 30, control 10.

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Pineda et al., 4 Oct 2022, prospective, Honduras, preprint, mean age 47.9, 24 authors, study period November 2020 - January 2022.

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